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KMID : 0377219940190010031
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Medical Journal of Chosun Univercity
1994 Volume.19 No. 1 p.31 ~ p.37
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Central Cardiovascular Effects of 5-Hydroxytryptamine in Anesthetized Rats
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Ban Jae-Hyun
Choi Hyo-Sub
Yeum Cheol-Ho
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Abstract
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This experiment was performed to examine the cardiovascular effects of 5-hydroxytryptamine(5-HT) administered intracerebroventricularly(ICV) in rats. Rats(male, Sprague-Dawley) weighing 220~280 g were used. They were anesthetized with pentobarbital sodium(50 mg/ kg, IP). 5-HT(I~40 ug) was administered into the right lateral ventricle, while blood pressure and heart rate were continuously recorded from the right femoral artery.
5-HT produced a biphasic response in arterial pressure. The initial transient pressor response was followed by a sustained fall of MAP, both of which were dose-dependent. The pressor as well as depressor response was accompanied by bradycardia. The pressor response was potentiated by pretreatment with cyproheptadine(10 ug, ICV), but was abolished by methysergide(10 ug, ICV). The depressor response to 5-HT was significantly attenuated following the treatment with methysergide(10 ug, ICV)or hexamethonium(2.5 mg/ kg/ min, IV). These results suggest that central cardiovascular effect to 5-HT is mediated by a ’5-HT_1 -like’ receptor mechanism and that the changes in peripheral sympathetic tone play a role, at least in part in its depressor effect.
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KEYWORD
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5-hydroxytryptamine, Central administration, Cardiovascular effects
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